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Sublingual compared with oral misoprostol for cervical dilatation prior to vacuum aspiration: a randomized comparison.

Abstract
The aim of the study was to compare the effect of oral and sublingual administration of misoprostol for cervical priming prior to vacuum aspiration. Thirty-two first-time-pregnant women with 8-12 weeks amenorrhea were randomly assigned to receive 400 microg misoprostol either orally or sublingually 3 h prior to surgery. The degree of baseline dilatation and the cumulative force needed for dilatation of the cervical canal did not differ between the two treatment groups. However, the number of patients in whom a strong force was needed was significantly higher following oral than following sublingual treatment. It was shown that sublingual administration is more effective than oral administration of misoprostol for cervical priming and is associated with less blood loss but a higher frequency of side effects.
AuthorsA Aronsson, L Helström, K Gemzell-Danielsson
JournalContraception (Contraception) Vol. 69 Issue 2 Pg. 165-9 (Feb 2004) ISSN: 0010-7824 [Print] United States
PMID14759623 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Abortifacient Agents, Nonsteroidal
  • Misoprostol
Topics
  • Abortifacient Agents, Nonsteroidal (administration & dosage)
  • Abortion, Induced (methods)
  • Administration, Oral
  • Administration, Sublingual
  • Adult
  • Female
  • Humans
  • Labor Stage, First (drug effects)
  • Misoprostol (administration & dosage)
  • Pregnancy
  • Vacuum Curettage

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