Effect of risperidone on prolactinoma--a case report.

Abstract

Risperidone induced galactorrhea and hyperprolactinemia have been reported but its role in the growth of prolactinoma is not yet conclusive, due to extreme rarity of such cases. We describe a woman, suffering from Bipolar Disorder-manic episode, who exhibited prolactinoma while on risperidone therapy. The withdrawal of risperidone resulted in disappearance of prolactinoma though her prolactin level remained elevated along with persistent galactorrhea. The change to olanzapine therapy did not show much change in serum prolactin level and galactorrhea. Ultimately, only adding of bromocriptine resulted in disappearance of symptoms of prolactinemia and normal serum prolactin level was achieved and galactorrhea stopped. Further study is recommended to find out relationship between the growth of prolactinoma and risperidone.

• Authors: D N Mendhekar, R C Jiloha, P K Srivastava
• Journal: Pharmacopsychiatry (Pharmacopsychiatry) Vol. 37 Issue 1 Pg. 41-2 (Jan 2004) ISSN: 0176-3679 [Print] Germany
• PMID: 14750048 (Publication Type: Case Reports, Letter)

Chemical References

• Antimanic Agents
• Antipsychotic Agents
• Lithium Carbonate
• Risperidone

Topics

• Adult
• Antimanic Agents (administration & dosage, adverse effects)
• Antipsychotic Agents (administration & dosage, adverse effects)
• Bipolar Disorder (drug therapy)
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Galactorrhea (chemically induced, diagnosis)
• Humans
• Lithium Carbonate (administration & dosage, adverse effects)
• Magnetic Resonance Imaging
• Pituitary Neoplasms (chemically induced, diagnosis)
• Prolactinoma (chemically induced, diagnosis)
• Risperidone (administration & dosage, adverse effects)
• Tomography, X-Ray Computed