Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism.

Abstract

BACKGROUND:

Guanine nucleotide-binding proteins (G-proteins) have been implicated in affective disorders, with reports of altered signal transduction and G-protein levels. Association with seasonal affective disorder (SAD) has been found for the higher activity T-allele of the G-protein beta-3-subunit C825T polymorphism.

METHODS:

European SAD patients (n = 159) and matched controls (n = 159) were genotyped for the C825T. Seasonality and diurnal preference were investigated in subsets of the material (n = 177 and 92, respectively).

RESULTS:

We found no association between C825T and SAD (chi(2) =.09, p =.96) or seasonality (F = 1.76, p =.18). There was some evidence for an effect on diurnal preference but only in the control group (n = 46, t = -2.8, Bonferroni corrected p =.045).

CONCLUSIONS:

These results suggest that the G-protein beta-3-subunit 825 T-allele does not play a major role in susceptibility to seasonal affective disorder in the population studied.

• Authors: Carolina Johansson, Matthäeus Willeit, Liviu Aron, Christina Smedh, Jenny Ekholm, Tiina Paunio, Tuula Kieseppä, Dirk Lichtermann, Nicole Praschak-Rieder, Alexander Neumeister, Siegfried Kasper, Leena Peltonen, Rolf Adolfsson, Timo Partonen, Martin Schalling
• Journal: Biological psychiatry (Biol Psychiatry) Vol. 55 Issue 3 Pg. 317-9 (Feb 01 2004) ISSN: 0006-3223 [Print] United States
• PMID: 14744475 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• G-protein beta3 subunit
• Cytosine
• Heterotrimeric GTP-Binding Proteins
• Thymine

Topics

• Alleles
• Case-Control Studies
• Cytosine
• Female
• Genetic Predisposition to Disease
• Genotype
• Heterotrimeric GTP-Binding Proteins (genetics)
• Humans
• Male
• Polymorphism, Single Nucleotide
• Seasonal Affective Disorder (genetics)
• Thymine