Psoriasiform eruption induced by infliximab.

Abstract

OBJECTIVE:

To report a case of psoriasiform eruption induced by infliximab.

CASE SUMMARY:

A 46-year-old woman with enterocutaneous fistula secondary to Crohn's disease developed pruriginous, erythematous, desquamative plaques on her elbows, knees, hands, and buttocks after receiving the second and third doses of intravenous infliximab. Histologic examination showed a lichenoid pattern. No new cutaneous lesions appeared after cessation of infliximab therapy.

DISCUSSION:

Several cutaneous reactions secondary to infliximab, a monoclonal antibody against tumor necrosis factor-alfa, have been described. Psoriasiform dermatitis has not been reported as a cutaneous reaction to infliximab, but there have been several previous reports of psoriasiform dermatitis secondary to other drugs. An objective causality assessment revealed that the adverse event was probable.

CONCLUSIONS:

This is the first report of a clinico-pathologic dissociated pattern of cutaneous reaction showing a histopathologic picture of lichenoid dermatitis resulting from infliximab treatment.

• Authors: María M Verea, Jesús Del Pozo, M Teresa Yebra-Pimentel, Angeles Porta, Eduardo Fonseca
• Journal: The Annals of pharmacotherapy (Ann Pharmacother) Vol. 38 Issue 1 Pg. 54-7 (Jan 2004) ISSN: 1060-0280 [Print] United States
• PMID: 14742794 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Methylprednisolone Acetate
• Infliximab
• Methylprednisolone

Topics

• Administration, Topical
• Antibodies, Monoclonal (administration & dosage, adverse effects, pharmacokinetics)
• Crohn Disease (complications, pathology)
• Drug Eruptions (complications, drug therapy, pathology)
• Female
• Hand Dermatoses (chemically induced, complications, drug therapy)
• Humans
• Infliximab
• Injections, Intravenous
• Intestinal Fistula (complications, pathology)
• Lichenoid Eruptions (chemically induced, complications, drug therapy)
• Methylprednisolone (administration & dosage, analogs & derivatives, therapeutic use)
• Methylprednisolone Acetate
• Middle Aged
• Psoriasis (chemically induced, complications, drug therapy)