Intranasal immunization of mice with group B streptococcal protein rib and cholera toxin B subunit confers protection against lethal infection.

Abstract

Intranasal immunization of mice with Rib, a cell surface protein of group B streptococcus (GBS), conjugated to or simply coadministered with the recombinant cholera toxin B subunit, induces systemic immunoglobulin G (IgG) and local IgA antibody responses and confers protection against lethal GBS infection. These findings have implications for the development of a human GBS vaccine.

• Authors: Charlotte Larsson, Jan Holmgren, Gunnar Lindahl, Charlotta Bergquist
• Journal: Infection and immunity (Infect Immun) Vol. 72 Issue 2 Pg. 1184-7 (Feb 2004) ISSN: 0019-9567 [Print] United States
• PMID: 14742572 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Bacterial Proteins
• Bacterial Vaccines
• Membrane Proteins
• Rib protein, Streptococcus agalactiae
• Vaccines, Conjugate
• Cholera Toxin

Topics

• Administration, Intranasal
• Animals
• Antibodies, Bacterial (blood)
• Antigens, Bacterial (immunology)
• Bacterial Proteins (immunology)
• Bacterial Vaccines (administration & dosage, immunology)
• Cholera Toxin (administration & dosage, immunology)
• Female
• Immunization
• Membrane Proteins (immunology)
• Mice
• Mice, Inbred C3H
• Streptococcal Infections (prevention & control)
• Streptococcus agalactiae (immunology)
• Vaccines, Conjugate (administration & dosage, immunology)