Role of Na+-Ca2+ exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na+-Ca2+ exchanger knockout mouse model.

Abstract

We used Na(+)-Ca(2+) exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mice hearts after ischemia/reperfusion and the infarct size was significantly small in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury.

• Authors: Masashi Ohtsuka, Hiroyuki Takano, Masashi Suzuki, Yunzeng Zou, Hiroshi Akazawa, Masaji Tamagawa, Koji Wakimoto, Haruaki Nakaya, Issei Komuro
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 314 Issue 3 Pg. 849-53 (Feb 13 2004) ISSN: 0006-291X [Print] United States
• PMID: 14741714 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Sodium-Calcium Exchanger
• Tetrazolium Salts
• Calcium

Topics

• Animals
• Calcium (chemistry, metabolism)
• Disease Models, Animal
• Heart (physiopathology)
• Hemodynamics (physiology)
• Heterozygote
• Male
• Mice
• Mice, Knockout
• Myocardial Infarction (metabolism)
• Myocardial Ischemia (metabolism)
• Myocardial Reperfusion Injury (metabolism, physiopathology)
• Myocardium (metabolism, pathology)
• Myocytes, Cardiac (physiology)
• Sodium-Calcium Exchanger (genetics, metabolism, physiology)
• Staining and Labeling (methods)
• Tetrazolium Salts (chemistry)