Abstract | PURPOSE: Hematogenic metastasis of patients with colorectal cancer most frequently effects the liver; the prognosis of affected patients is dramatically worsened by the presence of this lesion. The aim of this study was to evaluate the effect of hepatic arterial chemoembolization (HACE) with irinotecan versus 5-fluorouracil as a standard agent in a rat liver metastasis model. MATERIALS AND METHODS: RESULTS: HACE with irinotecan induced a complete remission in 44% of the animals and the highest dose reduced the mean tumor cell load by 66% (P < 0.001). In contrast, the highest dose of 5-FU caused a reduction of only 18% (P = 0.026) and altogether 23% complete remissions were observed in response to 5-FU. The sensitivity of CC531-lac-Z cells versus irinotecan (IC50 32 pM after 72 h) and 5-FU (IC50 80 microM) mirrored the effects observed in vivo on a qualitative basis. CONCLUSION: In conclusion, the effect of HACE with irinotecan surpassed that of HACE with 5-FU and prompts further investigation in clinical trials.
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Authors | Jan Saenger, Maike Leible, Matthias H Seelig, Martin R Berger |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 130
Issue 4
Pg. 203-10
(Apr 2004)
ISSN: 0171-5216 [Print] Germany |
PMID | 14740207
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Antineoplastic Agents, Phytogenic
- Irinotecan
- Fluorouracil
- Camptothecin
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Topics |
- Adenocarcinoma
(therapy)
- Animals
- Antimetabolites, Antineoplastic
(pharmacology, therapeutic use)
- Antineoplastic Agents, Phytogenic
(pharmacology, therapeutic use)
- Camptothecin
(analogs & derivatives, pharmacology, therapeutic use)
- Cell Line, Tumor
- Chemoembolization, Therapeutic
(methods)
- Colonic Neoplasms
(therapy)
- Dose-Response Relationship, Drug
- Fluorouracil
(pharmacology, therapeutic use)
- Irinotecan
- Luminescent Measurements
- Male
- Microspheres
- Rats
- Rats, Inbred Strains
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