HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

STAT1 knockout mice are highly susceptible to pulmonary mycobacterial infection.

Abstract
This study was designed to determine the roles of STAT1 protein in defense against mycobacterial infection. Airborne infection of STAT1 knockout (KO) mice with a Mycobacterium tuberculosis Kurono strain induced multiple necrotic lesions in lungs, spleen and liver, while that in wild-type (WT) mice did not. The STAT1 KO mice succumbed to mycobacterial infection by the 35th day after infection. Compared with the levels in WT mice, inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha, interferon-gamma and IL-12 mRNA levels were significantly lower in the lung of STAT1 KO mice. Interestingly, granulomatous lesion development in STAT1 KO mice was inhibited significantly by treatment with exogenous recombinant murine IL-12. Therefore, STAT1 regulates IL-12 expression and appears to be a critical transcription factor in controling mycobacterial infection.
AuthorsIsamu Sugawara, Hiroyuki Yamada, Satoru Mizuno
JournalThe Tohoku journal of experimental medicine (Tohoku J Exp Med) Vol. 202 Issue 1 Pg. 41-50 (Jan 2004) ISSN: 0040-8727 [Print] Japan
PMID14738323 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Immunologic
  • DNA-Binding Proteins
  • STAT1 Transcription Factor
  • Stat1 protein, mouse
  • Trans-Activators
  • Interleukin-12
Topics
  • Adjuvants, Immunologic
  • Animals
  • DNA-Binding Proteins (genetics, metabolism)
  • Genetic Predisposition to Disease
  • Interleukin-12 (pharmacology)
  • Liver (microbiology)
  • Lung (microbiology, pathology)
  • Mice
  • Mice, Knockout
  • Mycobacterium tuberculosis (pathogenicity)
  • Reverse Transcriptase Polymerase Chain Reaction
  • STAT1 Transcription Factor
  • Spleen (microbiology)
  • Time Factors
  • Trans-Activators (genetics, metabolism)
  • Tuberculosis (drug therapy, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: