Clindamycin in the treatment of Babesia gibsoni infections in dogs.

Abstract

This report examines the effectiveness of clindamycin for the treatment of babesiosis in dogs (n=10) experimentally infected with Babesia gibsoni (B. gibsoni). Clindamycin (25 mg/kg body weight, per os, q 12 hours for 14 days) gradually reduced parasitemia levels and induced morphological changes that indicated degeneration of parasites (e.g., segmentation; size reduction; localization in the cell limbic and/or torn state of the nucleus; and swelling, decrease, or disappearance of the cytoplasm) in the majority of dogs. Clindamycin treatment reduced the clinical symptoms characteristic of Babesia infection, including anemia, anorexia, and listlessness. Clindamycin might be useful as a medicine for treatment of B. gibsoni infection.

• Authors: Retno Wulansari, Agus Wijaya, Hitoshi Ano, Yoichiro Horii, Tetsuo Nasu, Shin-ichi Yamane, Susumu Makimura
• Journal: Journal of the American Animal Hospital Association (J Am Anim Hosp Assoc) 2003 Nov-Dec Vol. 39 Issue 6 Pg. 558-62 ISSN: 1547-3317 [Electronic] United States
• PMID: 14736722 (Publication Type: Journal Article)

Chemical References

• Antiprotozoal Agents
• Clindamycin

Topics

• Animals
• Antiprotozoal Agents (therapeutic use)
• Babesia (drug effects)
• Babesiosis (drug therapy, veterinary)
• Clindamycin (therapeutic use)
• Dog Diseases (drug therapy)
• Dogs
• Male
• Treatment Outcome