Genetics and Parkinson's disease.

Abstract

Idiopathic Parkinson's disease is a neurodegenerative disorder that affects 1-2% of the population over the age of 65 years. Its aetiology is most likely a combination of complex genetic and environmental factors. Although Mendelian inheritance is seen in less than 5% of cases, recent studies have identified three genes mutations causing Parkinson's disease with a Mendelian inheritance pattern: autosomal dominantly inherited mutations of the alpha-synuclein gene on chromosome 4q21-q23, autosomal recessively inherited mutations of the parkin gene on chromosome 6q25.2-q27 and an autosomal dominantly inherited mutation of the Ubiquitin C-terminal hydrolase L1 (UCH-L1) gene on chromosome 4p14-15.1. A number of other candidate gene polymorphisms including cytochrome P450 2D6, N-acetyltransferase 2, monoamine oxidase-B and glutathione-s-transferase M1 are implicated in sporadic and familial cases and may also play a minor role in the aetiology of Parkinson's disease.

• Authors: Dennis J Cordato, Daniel K Y Chan
• Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 11 Issue 2 Pg. 119-23 (Feb 2004) ISSN: 0967-5868 [Print] Scotland
• PMID: 14732367 (Publication Type: Journal Article, Review)

Chemical References

• Nerve Tissue Proteins

Topics

• Genetics
• Humans
• Nerve Tissue Proteins (genetics)
• Parkinson Disease (genetics)
• Polymorphism, Genetic