Association study of onset age, attempted suicide, aggressive behavior, and schizophrenia with a serotonin 1B receptor (A-161T) genetic polymorphism.

Abstract

Located on the presynaptic and postsynaptic terminals of serotonergic neurons, serotonin 1B receptors (5-HT1B) are involved in the modulation of serotonergic activity. The implications of 5-HT1B study of animal models of schizophrenia and antipsychotic activity involving defective sensory processes suggest that this receptor may be involved in the pathogenesis of schizophrenic disorders. In a population-based association study, we tested the hypothesis that the allelic variant, A-161T, of the 5-HT1B gene confers susceptibility to schizophrenic disorders and is associated with age of onset, aggressive behavior and attempted suicide. We genotyped the A-161T polymorphism in 110 patients with schizophrenic disorders and in 215 normal controls. No association was demonstrated between 5-HT1B genotype or allele frequencies and schizophrenic disorders, except for a trend for later age at disease onset in A/A homozygote schizophrenics in comparison with A/T heterozygote patients (p = 0.071). No significant difference in genotype distribution was determined comparing patients with and without aggressive behavior, and those with and without a history of suicide attempt. These findings suggest that the investigated 5-HT1B genetic polymorphism does not play a major role in the pathogenesis of schizophrenic disorders.

• Authors: Chen-Jee Hong, Guo-Mei Pan, Shih-Jen Tsai
• Journal: Neuropsychobiology (Neuropsychobiology) Vol. 49 Issue 1 Pg. 1-4 ( 2004) ISSN: 0302-282X [Print] Switzerland
• PMID: 14730192 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2004 S. Karger AG, Basel

Chemical References

• RNA, Messenger
• Receptor, Serotonin, 5-HT1B
• Threonine
• Alanine

Topics

• Adult
• Age of Onset
• Aggression
• Alanine (genetics)
• Case-Control Studies
• Female
• Gene Frequency
• Genotype
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)
• RNA, Messenger (biosynthesis)
• Receptor, Serotonin, 5-HT1B (genetics)
• Reverse Transcriptase Polymerase Chain Reaction (methods)
• Schizophrenia (complications, genetics, physiopathology)
• Schizophrenic Psychology
• Suicide, Attempted
• Threonine (genetics)