Sinonasal neuroendocrine carcinoma in association with SIADH.

Abstract

BACKGROUND:

Neuroendocrine carcinoma (NEC) is a rare malignancy of the nasal cavity or paranasal sinuses. The syndrome of inappropriate ADH secretion (SIADH) has not been previously reported in association with this cancer.

METHODS:

We report a 30-year-old woman with histologically confirmed neuroendocrine carcinoma who also demonstrated SIADH. After successful chemotherapy and radiotherapy treatment for the neoplasm, her SIADH resolved. A literature search found eight cases of olfactory neuroblastoma (ONB) associated with SIADH, four of which resolved after treatment of the malignancy.

RESULTS:

Treatment of the underlying malignancy resulted in the immediate resolution of the SIADH.

CONCLUSIONS:

We report the first case of SIADH associated with NEC, which resolved after treatment of the cancer. A direct cause and effect between ONB/nasal NEC and SIADH has been established in previous reports.

• Authors: Nilesh R Vasan, Jesus E Medina, Vikki A Canfield, Elizabeth M Gillies
• Journal: Head & neck (Head Neck) Vol. 26 Issue 1 Pg. 89-93 (Jan 2004) ISSN: 1043-3074 [Print] United States
• PMID: 14724912 (Publication Type: Journal Article)
• Copyright: Copyright 2004 Wiley Periodicals, Inc.

Topics

• Adult
• Carcinoma, Neuroendocrine (complications, therapy)
• Female
• Humans
• Inappropriate ADH Syndrome (complications, therapy)
• Nasal Cavity
• Nose Neoplasms (complications, therapy)