Subependymal giant cell astrocytoma with positive tuberin expression--case report.

Abstract

An 11-year-old male presented with subependymal giant cell astrocytoma (SEGA) without other manifestations of tuberous sclerosis such as facial angiofibroma, epilepsy, or mental retardation. The diagnosis was "possible tuberous sclerosis complex" (TSC). Total resection of the tumor was performed. Immunohistochemical study revealed positive tuberin expression. In general, loss of tuberin is thought to be critical to the TSC phenotype. Our case demonstrated clear expression of tuberin in the SEGA specimen.

• Authors: Sadaharu Tabuchi, Haruo Takigawa, Akira Oka, Masashi Mizuguchi, Yasushi Horie, Takashi Watanabe
• Journal: Neurologia medico-chirurgica (Neurol Med Chir (Tokyo)) Vol. 43 Issue 12 Pg. 616-8 (Dec 2003) ISSN: 0470-8105 [Print] Japan
• PMID: 14723270 (Publication Type: Case Reports, Journal Article)

Chemical References

• Repressor Proteins
• TSC2 protein, human
• Tuberous Sclerosis Complex 2 Protein
• Tumor Suppressor Proteins

Topics

• Astrocytoma (diagnosis, metabolism, surgery)
• Brain Neoplasms (diagnosis, metabolism, surgery)
• Child
• Humans
• Magnetic Resonance Imaging
• Male
• Microsurgery (methods)
• Neurosurgical Procedures (methods)
• Repressor Proteins (metabolism)
• Tomography, X-Ray Computed
• Tuberous Sclerosis Complex 2 Protein
• Tumor Suppressor Proteins