A patient with LQTS in whom verapamil administration and permanent pacemaker implantation were useful for preventing torsade de pointes.

Abstract

A 21-year-old woman with long QT syndrome and missense mutation in HERG (T613M), suffered from repeated attacks of pause dependent torsade de pointes, even though she was given beta-blockers and underwent stellate ganglion block twice at the age of eight. After she received permanent pacemaker implantation and administration of verapamil, no premature beats or pause dependent torsade de pointes was observed.

• Authors: Norihiro Komiya, Kyoei Tanaka, Yoshiyuki Doi, Satoki Fukae, Kojiro Nakao, Shojiro Isomoto, Shinji Seto, Katsusuke Yano
• Journal: Pacing and clinical electrophysiology : PACE (Pacing Clin Electrophysiol) Vol. 27 Issue 1 Pg. 123-4 (Jan 2004) ISSN: 0147-8389 [Print] United States
• PMID: 14720170 (Publication Type: Case Reports, Journal Article)

Chemical References

• Verapamil

Topics

• Adult
• Female
• Humans
• Long QT Syndrome (therapy)
• Pacemaker, Artificial
• Prosthesis Implantation
• Torsades de Pointes (prevention & control)
• Verapamil (therapeutic use)