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Prognostic significance and correlation with survival of bcl-2 and TGF-beta RII in colon cancer.

Abstract
Bcl-2 and TGF-beta receptors type II (RII) in colon carcinomas were studied in a series of 113 patients, to determine their prognostic significance and to correlate their expression with other prognostic indicators. Bcl-2 expression in the tumor cells showed a reverse relation with tumor size (P = 0.018), histological grade (P = 0.04), and stage (P = 0.013). Univariate survival analysis using the log rank test showed that the survival of patients with bcl-2-positive tumors was significantly better than the survival of patients with bcl-2-negative tumors (P = 0.02). However, when entered into a multivariate analysis model, it was not found to be of independent prognostic significance. TGF-beta RII expression was correlated with stage (P = 0.03), while no statistically significant correlation was found between TGF-beta RII expression and histological grade or survival. In conclusion, these results provide additional evidence for the role of bcl-2 and TGF-beta RII in carcinogenesis of the colon, while they do not support the use of these factors as prognostic markers in patients with colon cancer.
AuthorsGregory Kouraklis, John Kakisis, Stamatios Theoharis, Antonia Tzonou, Andromachi Glinavou, John Raftopoulos, Gabriel Karatzas
JournalDigestive diseases and sciences (Dig Dis Sci) Vol. 48 Issue 12 Pg. 2284-9 (Dec 2003) ISSN: 0163-2116 [Print] United States
PMID14714614 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Proto-Oncogene Proteins c-bcl-2
  • Receptors, Transforming Growth Factor beta
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (metabolism)
  • Colonic Neoplasms (metabolism, mortality)
  • Female
  • Greece (epidemiology)
  • Humans
  • Immunohistochemistry
  • Male
  • Prognosis
  • Proto-Oncogene Proteins c-bcl-2 (metabolism)
  • Receptors, Transforming Growth Factor beta (metabolism)
  • Survival Analysis

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