Abstract | OBJECTIVE: DESIGN: Prospective, randomized, blinded study. SETTING: Certified animal care facility. ANIMAL(S): Twenty-eight sexually mature, female New Zealand White rabbits. INTERVENTION(S): Animals were prospectively randomized (by number generator) to receive GnRH-a or saline. After 6 weeks, standard surgical manipulations were performed at three sites in each uterine horn by [1]. suture, [2]. unipolar cautery, and [3]. superficial abrasion. Interceed was applied over one randomly assigned uterine horn only. Six weeks after surgery, uterine adhesions were assessed visually, and tissue fibrosis was assessed by histology. MAIN OUTCOME MEASURE(S): Presence or absence of adhesions and microscopic tissue fibrosis. RESULT(S): CONCLUSION(S): Preoperative GnRH-a is more effective than Interceed in preventing surgical adhesions in the rabbit uterine horn. However, preoperative GnRH-a plus Interceed may provide optimal results in this animal model, because microscopic tissue fibrosis is minimized with this combination.
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Authors | Paul B Marshburn, James M Meek, Helen E Gruber, Brian E Gordon, James H Norton, Bradley S Hurst |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 81
Issue 1
Pg. 194-7
(Jan 2004)
ISSN: 0015-0282 [Print] United States |
PMID | 14711566
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cellulose, Oxidized
- INTERCEED
- Gonadotropin-Releasing Hormone
- Leuprolide
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Topics |
- Animals
- Cellulose, Oxidized
(therapeutic use)
- Disease Models, Animal
- Drug Therapy, Combination
- Female
- Fibrosis
(prevention & control)
- Gonadotropin-Releasing Hormone
(agonists)
- Gynecologic Surgical Procedures
(adverse effects)
- Leuprolide
(therapeutic use)
- Postoperative Complications
(prevention & control)
- Preoperative Care
(methods)
- Prospective Studies
- Rabbits
- Random Allocation
- Regression Analysis
- Tissue Adhesions
- Uterus
(pathology, surgery)
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