HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Antibiotics and other anti-infective agents in pregnancy and lactation.

Abstract
Serum levels of many drugs are lower in pregnancy compared with the nonpregnant state. Their renal clearance is higher and the maternal intravascular volume is expanded. Most antibiotics are safe for use in pregnancy and lactation. Tetracyclines cause fetal tooth discoloration and inhibition of bone growth if used in the second and third trimesters. Aminoglycosides carry a small risk of fetal ototoxicity. Quinolones may cause arthropathies in children, and so are currently not recommended for use in pregnancy. Most drugs are secreted into breast milk in very small amounts, not enough to have any therapeutic effect. The only antibiotics which may be of concern in nursing infants are sulfonamides and quinolones, and possibly metronidazole.
AuthorsJennifer R Niebyl
JournalAmerican journal of perinatology (Am J Perinatol) Vol. 20 Issue 8 Pg. 405-14 (Nov 2003) ISSN: 0735-1631 [Print] United States
PMID14703588 (Publication Type: Journal Article, Review)
Chemical References
  • Aminoglycosides
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antiviral Agents
  • Drug Combinations
  • Penicillins
  • Quinolones
  • Tetracyclines
Topics
  • Aminoglycosides (therapeutic use)
  • Anti-Bacterial Agents (therapeutic use)
  • Anti-Infective Agents (therapeutic use)
  • Antiviral Agents (therapeutic use)
  • Drug Combinations
  • Female
  • Humans
  • Influenza, Human (drug therapy, prevention & control)
  • Lactation (drug effects)
  • Penicillins (therapeutic use)
  • Pregnancy (drug effects)
  • Pregnancy Complications, Infectious (drug therapy, prevention & control)
  • Quinolones (therapeutic use)
  • Tetracyclines (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: