[Efficacy of gamma knife radiosurgery in treatment of growth hormone-secreting pituitary adenoma].

Abstract

OBJECTIVE:

To evaluate the efficacy of gamma knife radiosurgery (GKS) in treatment of growth hormone (GH)-secreting pituitary adenoma.

METHODS:

149 patients with GH-secreting pituitary adenoma, 97 males and 52 females, aged 42.8 (12-72 years), with a course of 6-240 months (72.5 months) and with the mean volume of tumor of 2.36 cm(3) (0.11-12.7 cm(3)) were treated by GKS. The mean dose to tumor margin was 20.87 Gy (10-30 Gy). 124 of them were followed up for 30 months (6-72 months).

RESULTS:

The serum GH returned normal in 74 patients (64.9%) and declined in comparison with the level before radiosurgery in 23 patients (18.5%). The tumor volume was reduced in 84 patients (67.7%) and remained unchanged in 124 patients (32.4%). Ambiopia appeared in one patient. No other complication was found during the follow-up.

CONCLUSION:

GKS is safe and effective on the treatment of GH-secreting pituitary adenoma.

• Authors: Mei-hua Wang, Peng Liu, A-li Liu, Bin Luo, Shi-bin Sun
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 83 Issue 23 Pg. 2045-8 (Dec 10 2003) ISSN: 0376-2491 [Print] China
• PMID: 14703413 (Publication Type: Journal Article)

Chemical References

• Human Growth Hormone

Topics

• Adenoma (surgery)
• Adolescent
• Adult
• Aged
• Female
• Human Growth Hormone (blood, metabolism)
• Humans
• Male
• Middle Aged
• Pituitary Neoplasms (surgery)
• Radiosurgery (adverse effects)