Abstract | BACKGROUND: METHODS: At laparotomy, 1 to 2 mL of isosulfan blue and 1 mCi of TSC were injected subserosally. Sentinel lymph node (SLN) designation was based on blue staining for isosulfan blue and increased radioactivity for TSC. Focused pathologic analysis of the SLNs and standard pathologic examination of the remaining specimen were performed. RESULTS: A total of 57 consecutive patients were studied (median age, 71 years; 27 men and 30 women). Mapping was successful in 100% of patients with isosulfan blue and in 89% with TSC (P =.47). Lymphatic mapping was accurate in 93% of patients with isosulfan blue versus 92% with TSC (P =.53). The combined accuracy was 95%. A total of 709 lymph nodes were found (12.4 per patient): 553 non-SLNs (5.6% nodal positivity) versus 156 SLNs (16.7% nodal positivity; P <.0001). Isosulfan blue detected 152 SLNs, TSC detected 100, and both modalities detected 96. Of the SLNs detected by isosulfan blue only, 10.7% had nodal metastases, whereas 19.8% of SLNs detected with both modalities had nodal metastases (P =.028). Nodal disease was detected in 41% of patients with invasive carcinoma. Metastases were detected only in the SLNs in 26% and only by micrometastases in 11% of these patients. CONCLUSIONS:
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Authors | Sukamal Saha, Adrian G Dan, Blake Berman, David Wiese, Elie Schochet, Kimberly Barber, Sharan Choudhri, Sunil Kaushal, Balvant Ganatra, Delip Desai, Marigowda Nagaraju, S Mannam |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 11
Issue 1
Pg. 21-6
(Jan 2004)
ISSN: 1068-9265 [Print] United States |
PMID | 14699029
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Radiopharmaceuticals
- Rosaniline Dyes
- iso-sulfan blue
- Technetium Tc 99m Sulfur Colloid
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Topics |
- Aged
- Colorectal Neoplasms
(pathology)
- Female
- Humans
- Lymphatic Metastasis
- Male
- Prospective Studies
- Radiopharmaceuticals
- Rosaniline Dyes
- Sentinel Lymph Node Biopsy
- Technetium Tc 99m Sulfur Colloid
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