Abstract | BACKGROUND: METHODS: The purpose of this study was to investigate the potential for laser revascularization in ischemic skeletal muscle. Eighteen rabbits (3-4 kg) were instrumented chronically with transit time ultrasound flowprobes on both common iliac arteries. All rabbits performed graded exercise tests on a treadmill where maximal blood flow was recorded. Unilateral hindlimb ischemia was produced by ligation of one femoral artery. At week 3 postligation, 10 rabbits received laser therapy and 8 underwent a sham surgery. In each of four muscles (gracilius, medialis, sartorius, and biceps femoris) 5 to 22 laser channels were created (average = 52 channels per leg). RESULTS: At week 3 postligation the maximal blood flow of the ischemic limb for the treated group was 64 +/- 3 ml/min (mean +/- SEM) and at 6 weeks postlaser therapy maximal blood flow increased to 75 +/- 5 ml/min. The sham surgery group had a maximal blood flow of 58 +/- 4 ml/min at week 3 postligation and 66 +/- 3 ml/min at week 6 postsham surgery. CONCLUSION:
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Authors | John B Buckwalter, Valerie C Curtis, Stephen B Ruble, Zoran Valic, Jason J Hamann, R L Coon, M Mirhoseini, Philip S Clifford |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 115
Issue 2
Pg. 257-64
(Dec 2003)
ISSN: 0022-4804 [Print] United States |
PMID | 14697292
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Topics |
- Animals
- Blood Pressure
- Disease Models, Animal
- Heart Rate
- Iliac Artery
- Ischemia
(surgery)
- Laser Therapy
- Ligation
- Muscle, Skeletal
(blood supply, physiology)
- Neovascularization, Physiologic
- Peripheral Vascular Diseases
(surgery)
- Physical Exertion
- Rabbits
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