Abstract |
We successfully treated a child with parkinsonism secondary to cytosine arabinoside with levodopa/ carbidopa and attempted to elucidate the pathogenesis of the disorder by sequential analysis of cerebrospinal fluid biogenic amines, sequential magnetic resonance imaging, and fluorodopa positron emission tomography, which revealed both permanent and reversible biochemical and structural alterations. The parkinsonian disorder resolved in 9 months. Metabolic changes and structural abnormalities on imaging studies were chronologically correlated with the clinical course.
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Authors | Abe M Chutorian, Aviva Bojko, Linda Heier, Steven Frucht, Toby Nygaard, David Edelberg |
Journal | Journal of child neurology
(J Child Neurol)
Vol. 18
Issue 11
Pg. 812-5
(Nov 2003)
ISSN: 0883-0738 [Print] United States |
PMID | 14696914
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Antiparkinson Agents
- Cytarabine
- Levodopa
- Carbidopa
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Topics |
- Antimetabolites, Antineoplastic
(adverse effects)
- Antiparkinson Agents
(administration & dosage)
- Carbidopa
(administration & dosage)
- Child
- Cytarabine
(adverse effects)
- Humans
- Levodopa
(administration & dosage)
- Male
- Parkinson Disease, Secondary
(chemically induced, drug therapy, metabolism)
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