[Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].

Abstract

Effects of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment were investigated. One or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema. UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models, but not the side effect of it. These results suggest that Bearberry leaf increases the inhibitory effect of dexamethasone on the allergic and inflammatory models.

• Authors: H Matsuda, S Nakamura, T Tanaka, M Kubo
• Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (Yakugaku Zasshi) Vol. 112 Issue 9 Pg. 673-7 (Sep 1992) ISSN: 0031-6903 [Print] Japan
• PMID: 1469616 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Ointments
• Dexamethasone

Topics

• Animals
• Dermatitis, Contact (drug therapy)
• Dexamethasone (therapeutic use)
• Disease Models, Animal
• Drug Synergism
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Edema (drug therapy)
• Female
• Male
• Mice
• Ointments
• Rats
• Rats, Wistar