Abstract |
Effects of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment were investigated. One or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema. UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models, but not the side effect of it. These results suggest that Bearberry leaf increases the inhibitory effect of dexamethasone on the allergic and inflammatory models.
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Authors | H Matsuda, S Nakamura, T Tanaka, M Kubo |
Journal | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
(Yakugaku Zasshi)
Vol. 112
Issue 9
Pg. 673-7
(Sep 1992)
ISSN: 0031-6903 [Print] Japan |
PMID | 1469616
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- Ointments
- Dexamethasone
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Topics |
- Animals
- Dermatitis, Contact
(drug therapy)
- Dexamethasone
(therapeutic use)
- Disease Models, Animal
- Drug Synergism
- Drug Therapy, Combination
- Drugs, Chinese Herbal
(therapeutic use)
- Edema
(drug therapy)
- Female
- Male
- Mice
- Ointments
- Rats
- Rats, Wistar
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