New cinnamylphenols from Dalbergia species with cancer chemopreventive activity.

Abstract

Five new cinnamylphenols (1,3-diphenylpropenes), dalberatins A (1), B (2), C (3), D (4), and E (5), were isolated from plants of the Dalbergia species. They were characterized and tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The cinnamylphenols were found to show remarkably potent activities. The result of the present investigation indicated that some of these cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).

• Authors: Chihiro Ito, Masataka Itoigawa, Tetsufumi Kanematsu, Nijsiri Ruangrungsi, Hiroshi Higashihara, Harukuni Tokuda, Hoyoku Nishino, Hiroshi Furukawa
• Journal: Journal of natural products (J Nat Prod) Vol. 66 Issue 12 Pg. 1574-7 (Dec 2003) ISSN: 0163-3864 [Print] United States
• PMID: 14695799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Antigens, Viral
• Epstein-Barr virus early antigen
• Phenols
• Tetradecanoylphorbol Acetate

Topics

• Anticarcinogenic Agents (chemistry, isolation & purification, pharmacology)
• Antigens, Viral (drug effects)
• Dalbergia (chemistry)
• Humans
• Lymphoma, B-Cell
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Phenols (chemistry, isolation & purification, pharmacology)
• Plants, Medicinal (chemistry)
• Tetradecanoylphorbol Acetate (pharmacology)
• Thailand