Abstract |
A rheumatoid arthritis (RA) patient treated with low-dose methotrexate (MTX) therapy suffered from hemophagocytic syndrome (HPS) associated with B-cell lymphoma (B-LAHS). Administration of acyclovir and intravenous immunoglobulin promptly resolved laboratory test abnormalities accompanied with HPS. Moreover, hemophagocytic histiocytes and lymphoma cells in the bone marrow disappeared without anti- cancer therapy. Two months after reintroduction of MTX for RA flare, lymphoma re-grew rapidly without bone marrow involvement and HPS. Two cycles of combination chemotherapy induced the lymphoma to a complete remission/unconfirmed (CRu), but then the chemotherapy was discontinued due to severe side effects. In this case, on the basis of RA and MTX induced immunosuppressive state, Epstein-Barr virus ( EBV) infection was associated with the development of HPS and lymphoma. Anti-viral therapy alone was effective against HPS and lymphoma at initial presentation and improved her general condition. This case indicates that anti- cancer therapy should be preceded by anti-viral therapy and withdrawal of immunosuppressive therapy in patients under immunosuppressive therapy, as long as the clinical situation permits.
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Authors | Hiroshi Gomyo, Manabu Shimoyama, Kentaro Minagawa, Kimikazu Yakushijin, Norinaga Urahama, Atsuo Okamura, Katsuya Yamamoto, Mitsuhiro Ito, Kazuo Chihara, Toshimitsu Matsui |
Journal | Leukemia & lymphoma
(Leuk Lymphoma)
Vol. 44
Issue 10
Pg. 1807-10
(Oct 2003)
ISSN: 1042-8194 [Print] United States |
PMID | 14692538
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antirheumatic Agents
- Antiviral Agents
- Acyclovir
- Methotrexate
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Topics |
- Acyclovir
(therapeutic use)
- Aged
- Antirheumatic Agents
(therapeutic use)
- Antiviral Agents
(therapeutic use)
- Arthritis, Rheumatoid
(complications)
- Epstein-Barr Virus Infections
(diagnosis, drug therapy)
- Female
- Herpesvirus 4, Human
(isolation & purification)
- Histiocytosis, Non-Langerhans-Cell
(drug therapy, etiology)
- Humans
- Lymphoma, B-Cell
(complications, drug therapy)
- Methotrexate
(therapeutic use)
- Syndrome
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