Carbonic anhydrase inhibitors. inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions.

Abstract

Except for sulfonamides, metal complexing anions represent the second class of inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1). The first inhibition study of the transmembrane, tumor-associated isozyme CA IX with anions is reported here. Inhibition data of the cytosolic isozymes CA I and CA II with a large number of anionic species such as halides, pseudohalides, bicarbonate, nitrate, hydrosulfide, arsenate, etc., are also provided for comparison. Isozyme IX has an inhibition profile by anions different in some aspects from those of CA I and CA II, that may have interesting physiological consequences.

• Authors: Daniela Vullo, Marco Franchi, Enzo Gallori, Jaromir Pastorek, Andrea Scozzafava, Silvia Pastorekova, Claudiu T Supuran
• Journal: Journal of enzyme inhibition and medicinal chemistry (J Enzyme Inhib Med Chem) Vol. 18 Issue 5 Pg. 403-6 (Oct 2003) ISSN: 1475-6366 [Print] England
• PMID: 14692506 (Publication Type: Journal Article)

Chemical References

• Anions
• Carbonic Anhydrase Inhibitors
• Isoenzymes
• Carbon Dioxide
• Carbonic Anhydrases

Topics

• Anions (pharmacology)
• Carbon Dioxide (metabolism)
• Carbonic Anhydrase Inhibitors (pharmacology)
• Carbonic Anhydrases (genetics, metabolism)
• Humans
• Isoenzymes (antagonists & inhibitors, genetics, metabolism)
• Neoplasms (enzymology)