Abstract | BACKGROUND: The risk of port site metastasis in laparoscopic surgery for cancer patients is a problem that has yet to be resolved. We examined the protective effect of a sodium hyaluronate-based bioresorbable membrane ( Seprafilm) on tumor cell implantation at laparoscopic trocar sites. METHODS: RESULTS:
Seprafilm significantly decreased the incidence of implantation compared with the control group. Histologically, Seprafilm was observed on days 1 and 3, as a sheet of gel that covered the injured peritoneum and muscle layer. In an invasion assay using Seprafilm, no cells were found to infiltrate through the gel sheet. CONCLUSION:
Seprafilm protects peritoneal wounds by physically covering the injured peritoneum. Therefore, if Seprafilm were attached to the injured peritoneum after laparoscopic surgery for cancer patients, it might reduce port site metastasis.
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Authors | T Sasaki, H Shimura, T Tanaka, K Nakashima, K Matsuo, S Ikeda |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 18
Issue 2
Pg. 246-51
(Feb 2004)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 14691710
(Publication Type: Journal Article)
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Chemical References |
- Biocompatible Materials
- Gels
- Membranes, Artificial
- Seprafilm
- Hyaluronic Acid
- Carboxymethylcellulose Sodium
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Topics |
- Adenocarcinoma
(pathology, prevention & control, secondary, surgery)
- Animals
- Biocompatible Materials
(administration & dosage, therapeutic use)
- Carboxymethylcellulose Sodium
(administration & dosage, therapeutic use)
- Cell Line, Tumor
- Cholecystectomy, Laparoscopic
(adverse effects, methods)
- Gallbladder Neoplasms
(pathology, surgery)
- Gels
- Humans
- Hyaluronic Acid
(administration & dosage, therapeutic use)
- Implants, Experimental
- Male
- Membranes, Artificial
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Seeding
- Peritoneal Neoplasms
(etiology, prevention & control)
- Surgical Instruments
- Xenograft Model Antitumor Assays
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