Abstract | BACKGROUND AND PURPOSE:
Gastrointestinal stromal tumors (GISTs), identified by the presence of CD117 (KIT), were previously classified as gastric and intestinal smooth muscle tumors prior to the availability of immunohistochemical methods. This study evaluated the percentage of GISTs previously diagnosed as gastric smooth muscle tumors in our hospital during an 11-year period. METHODS: A total of 81 surgically resected gastric smooth muscle tumor specimens from 81 patients were collected from January 1986 to December 1997. Immunohistochemical studies were performed on these tumors with antibodies of CD34, CD117, smooth muscle actin (SMA), S-100, and desmin. RESULTS: Among the 81 tumors, 74 (91.4%) were CD117-positive and were classified as GISTs. Among the 74 GISTs, CD34 was positive in 72 tumors (97.3%), SMA was positive in 12 tumors (16.2%), desmin was positive in 5 tumors (6.7%), and S-100 was positive in 4 tumors (5.4%). The 7 tumors classified as non-GISTs had the following immunohistochemical characteristics: 1 was a CD117-negative CD34-positive stromal tumor (GINST) [1/81, 1.2%]; 3 were schwannomas with strong S-100-positive characteristics (3/81, 3.7%); and 3 were smooth muscle tumors with both SMA- and desmin-positive status (3/81, 3.7%). No clear relationship between CD117 or CD34 expression and prognosis was found for these tumors. CONCLUSIONS:
|
Authors | Tsung-Hui Hu, Jui-Wei Lin, Chi-Sin Changchien, Shang-Yun Liu, Shue-Shian Chiou, Jiin-Haur Chuang |
Journal | Journal of the Formosan Medical Association = Taiwan yi zhi
(J Formos Med Assoc)
Vol. 102
Issue 10
Pg. 707-14
(Oct 2003)
ISSN: 0929-6646 [Print] Singapore |
PMID | 14691596
(Publication Type: Journal Article)
|
Chemical References |
- Actins
- Antigens, CD34
- Biomarkers, Tumor
- Desmin
- S100 Proteins
- Proto-Oncogene Proteins c-kit
|
Topics |
- Actins
(metabolism)
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD34
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Desmin
(metabolism)
- Female
- Gastrointestinal Neoplasms
(metabolism, pathology)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Proto-Oncogene Proteins c-kit
(metabolism)
- Retrospective Studies
- S100 Proteins
(metabolism)
- Stromal Cells
(metabolism, pathology)
- Taiwan
|