[Correlation between the expression of collgen IV, VEGF and vasculogenic mimicry].

Abstract

OBJECTIVE:

To study the relationship between collgen (Col) IV, VEGF secreted by the tumor cells and vasculogenic mimicry (VM).

METHODS:

158 bi-phase differential malignant tumor specimens were alloted and made into tissue microarray. These tissue microarray sections were stained with CD31, periodic acid-Schiff (PAS) and Col IV. Subsequently, distributive trait of Col IV and the difference of VEGF expression were analyzed.

RESULTS:

The basement membrane of VM was PAS and Col IV positive. The expression of VEGF in bi-phase differential malignant tumor with VM was less than that in those without VM. The difference of VEGF expression in malignant melanoma and alveolar rhabdomyosarcoma was significant (P < 0.05).

CONCLUSION:

Collgen IV and periodic acid-Schiff positive material take part in constructing the basement membrane of vasculogenic mimicry. The difference of the VEGF expression proves that vasculogenic mimicry can sustain the tumor blood supply.

• Authors: Xi-shan Hao, Bao-cun Sun, Shi-wu Zhang, Xiu-lan Zhao
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 25 Issue 6 Pg. 524-6 (Nov 2003) ISSN: 0253-3766 [Print] China
• PMID: 14690552 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Collagen Type IV
• Vascular Endothelial Growth Factor A

Topics

• Collagen Type IV (analysis)
• Humans
• Immunohistochemistry
• Neoplasms (blood supply, chemistry, pathology)
• Periodic Acid-Schiff Reaction
• Vascular Endothelial Growth Factor A (analysis)