Abstract | OBJECTIVE: To study the relationship between collgen (Col) IV, VEGF secreted by the tumor cells and vasculogenic mimicry (VM). METHODS: 158 bi-phase differential malignant tumor specimens were alloted and made into tissue microarray. These tissue microarray sections were stained with CD31, periodic acid-Schiff (PAS) and Col IV. Subsequently, distributive trait of Col IV and the difference of VEGF expression were analyzed. RESULTS: The basement membrane of VM was PAS and Col IV positive. The expression of VEGF in bi-phase differential malignant tumor with VM was less than that in those without VM. The difference of VEGF expression in malignant melanoma and alveolar rhabdomyosarcoma was significant (P < 0.05). CONCLUSION: Collgen IV and periodic acid-Schiff positive material take part in constructing the basement membrane of vasculogenic mimicry. The difference of the VEGF expression proves that vasculogenic mimicry can sustain the tumor blood supply.
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Authors | Xi-shan Hao, Bao-cun Sun, Shi-wu Zhang, Xiu-lan Zhao |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 25
Issue 6
Pg. 524-6
(Nov 2003)
ISSN: 0253-3766 [Print] China |
PMID | 14690552
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Collagen Type IV
- Vascular Endothelial Growth Factor A
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Topics |
- Collagen Type IV
(analysis)
- Humans
- Immunohistochemistry
- Neoplasms
(blood supply, chemistry, pathology)
- Periodic Acid-Schiff Reaction
- Vascular Endothelial Growth Factor A
(analysis)
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