Abstract |
This retrospective study describes three clinically different groups of patients with symptomatic androgen-independent prostate cancer ( AIPC) referred to palliative radiotherapy (RT): those with a symptomatic pelvic tumour and pelvis-confined disease (M0 P-RT: 35 patients), those with a symptomatic pelvic tumour and distant metastases (M + P-RT: 97 patients) and those with painful bone metastases (BM-RT: 193 patients). The study emphasises the need of a combined surgical and radiotherapeutic palliation in AIPC patients with symptomatic pelvic tumours. Median overall survival from time of palliative RT was 19, 9 and 8 months for M0 P-RT, M + P-RT and BM-RT patients, respectively (p < 0.001). The significantly prolonged natural course of P-RT patients without distant metastases has to be accounted for in clinical trials of AIPC patients in whom survival represents an endpoint. Furthermore, the optimal palliation regimens for P-RT patients are still to be defined.
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Authors | Eivor Hernes, Sophie D Fosså, Eva Skovlund |
Journal | Acta oncologica (Stockholm, Sweden)
(Acta Oncol)
Vol. 42
Issue 7
Pg. 749-55
( 2003)
ISSN: 0284-186X [Print] England |
PMID | 14690161
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androgen Antagonists
- Antineoplastic Agents, Hormonal
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Topics |
- Aged
- Androgen Antagonists
(therapeutic use)
- Antineoplastic Agents, Hormonal
(therapeutic use)
- Bone Neoplasms
(radiotherapy, secondary)
- Combined Modality Therapy
- Drug Resistance, Neoplasm
- Humans
- Male
- Middle Aged
- Palliative Care
- Pelvic Neoplasms
(radiotherapy, secondary)
- Prostatic Neoplasms
(pathology, radiotherapy, surgery)
- Retrospective Studies
- Survival Analysis
- Tomography, X-Ray Computed
- Treatment Outcome
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