Abstract | BACKGROUND: METHODS: Age-matched male patients with primary intercritical gout and healthy male adults were included in the study. The serum concentrations of oxidized LDL autoantibodies and total antioxidant status were measured using an enzyme immunoassay. RESULTS: Serum concentrations of oxidized LDL autoantibodies were significantly higher in patients with gout than the control subjects (p < 0.05) and were significantly decreased after allopurinol treatment (p < 0.05), but not by benzbromarone treatment, in spite of the similar concentrations of uric acid and total antioxidant status in serum following their separate administration. CONCLUSIONS:
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Authors | Zenta Tsutsumi, Yuji Moriwaki, Sumio Takahashi, Tsuneyoshi Ka, Tetsuya Yamamoto |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 339
Issue 1-2
Pg. 117-22
(Jan 2004)
ISSN: 0009-8981 [Print] Netherlands |
PMID | 14687901
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antioxidants
- Autoantibodies
- Cholesterol, HDL
- Cholesterol, LDL
- Lipoproteins, LDL
- Triglycerides
- oxidized low density lipoprotein
- Uric Acid
- Allopurinol
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Topics |
- Allopurinol
(pharmacology, therapeutic use)
- Antioxidants
(analysis, metabolism)
- Autoantibodies
(blood, immunology)
- Body Weight
- Case-Control Studies
- Cholesterol, HDL
(blood, metabolism)
- Cholesterol, LDL
(blood, chemistry)
- Gout
(blood, drug therapy, immunology)
- Humans
- Lipoproteins, LDL
(blood, immunology)
- Male
- Middle Aged
- Smoking
- Triglycerides
(blood, metabolism)
- Uric Acid
(antagonists & inhibitors, metabolism)
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