HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma.

Abstract
While the usual or myxoid-type neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.
AuthorsRobert N Page, Roy King, Martin C Mihm Jr, Paul B Googe
JournalModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (Mod Pathol) Vol. 17 Issue 2 Pg. 230-4 (Feb 2004) ISSN: 0893-3952 [Print] United States
PMID14685254 (Publication Type: Journal Article)
Chemical References
  • DNA-Binding Proteins
  • MITF protein, human
  • Microphthalmia-Associated Transcription Factor
  • S100 Proteins
  • Transcription Factors
Topics
  • Adolescent
  • Adult
  • Child
  • DNA-Binding Proteins (biosynthesis)
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Microphthalmia-Associated Transcription Factor
  • Middle Aged
  • Neurothekeoma (metabolism, pathology)
  • S100 Proteins (biosynthesis)
  • Skin Neoplasms (metabolism, pathology)
  • Transcription Factors (biosynthesis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: