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A powerful new strategy for diversity-oriented synthesis of pyrroles from donor-acceptor cyclopropanes and nitriles.

Abstract
Lewis acid activated donor-acceptor cyclopropanes react with aliphatic, aromatic, and alpha,beta-unsaturated nitriles in a novel cascade [3 + 2] dipolar cycloaddition, dehydration, and tautomerization sequence to afford pyrroles in moderate to excellent overall yield. This cost-effective and regiospecific method is ideally suited for the preparation of combinatorial libraries. [reaction: see text]
AuthorsMing Yu, Brian L Pagenkopf
JournalOrganic letters (Org Lett) Vol. 5 Issue 26 Pg. 5099-101 (Dec 25 2003) ISSN: 1523-7060 [Print] United States
PMID14682774 (Publication Type: Journal Article)

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