Water-in-oil emollients as steroid-sparing adjunctive therapy in the treatment of psoriasis.

Abstract

An open label study of ninety-six patients with chronic plaque-type psoriasis demonstrated the efficacy of the addition of water-in-oil emollients to a topical corticosteroid regimen. Twice daily application of betamethasone dipropionate cream and once daily application of both betamethasone dipropionate cream and either a water-in-oil based moisturizing cream or lotion were equivalent in efficacy (p = 0.05). Once daily application of both betamethasone dipropionate cream and either a water-in-oil based cream or lotion was significantly better than once daily application of betamethasone dipropionate cream alone (p = 0.05). Water-in-oil emollients are useful in the therapy of chronic, plaque-type psoriasis and provide a steroid-sparing effect.

• Authors: K L Watsky, L Freije, M C Leneveu, H A Wenck, D J Leffell
• Journal: Cutis (Cutis) Vol. 50 Issue 5 Pg. 383-6 (Nov 1992) ISSN: 0011-4162 [Print] United States
• PMID: 1468261 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Emollients
• Oils
• Water
• Betamethasone

Topics

• Administration, Cutaneous
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Betamethasone (administration & dosage)
• Chronic Disease
• Emollients (therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Oils
• Psoriasis (drug therapy, pathology)
• Water