Abstract | BACKGROUND: MATERIAL AND METHODS: The study group consisted of 21 patients with asthma and intolerance of non steroids antiinflammatory drugs (F 19, M 2) in age from 21 to 72 years old (mean = 49 +/- 14), with middle time of asthma duration mean = 13.4 +/- 12.9 years In study group 11 person had positive skin test, 7 nasal polyps, and 8 person positive family history of bronchial asthma. After oral provocation aspirin challenge in 5 subjects' aspirin induced asthma was confirmed, 3 persons were not qualified to test. Urinary concentration of LTE4 before and 24 h after aspirin provocation was analyzed in all the patients. Leukotriene were detected by enzymatic Leukotriene E4, EIA Kit, Cayman Chemical test. RESULTS: In group of patients with aspirin asthma basic concentration of LTE4 was 416.6 +/- 374.4 pg/mL, and after provocation 496.6 +/- 485.3 pg/mL, in the group without sensitivity to aspirin appropriate 262.9 +/- 404.0 vs 261.2 +/- 259.66 pg/mL, and in the group disqualified to test 181.6 +/- 55.75 pg/mL. CONCLUSION:
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Authors | Renata Rubinsztajn, Jolanta Wrońska, Ryszarda Chazan |
Journal | Polskie Archiwum Medycyny Wewnetrznej
(Pol Arch Med Wewn)
Vol. 110
Issue 2
Pg. 849-54
(Aug 2003)
Poland |
Vernacular Title | Stezenie leukotrienów E4 w moczu chorych na astme oskrzelowa z nietolerancja NLPZ w wywiadzie przed doustna prowokacja aspiryna i po prowokacji. |
PMID | 14682223
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Leukotriene E4
- Aspirin
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Topics |
- Adult
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects, urine)
- Aspirin
(adverse effects, urine)
- Asthma
(urine)
- Bronchial Provocation Tests
(methods)
- Drug Hypersensitivity
(etiology, urine)
- Female
- Humans
- Leukotriene E4
(urine)
- Male
- Middle Aged
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