Progressive multifocal leukoencephalopathy in an adult patient with ICF syndrome.

Abstract

We report on a patient affected by ICF syndrome (immunodeficiency, centromeric instability of chromosomes 1, 9 and 16 and facial dysmorphism), who presented with slowing in mentation, mild right hemiparesis and focal motor seizures. MRI study of the brain suggested a diagnosis of progressive multifocal leukoencephalopathy (PML), which was confirmed by JC virus DNA detection on CSF by polymerase chain reaction (PCR). This is a unique case of adult infective neurological complication described in ICF Syndrome.

• Authors: Monica Colucci, Leonardo Cocito, Elisabetta Capello, Gian Luigi Mancardi, Carlo Serrati, Paola Cinque, Angelo Schenone
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 217 Issue 1 Pg. 107-10 (Jan 15 2004) ISSN: 0022-510X [Print] Netherlands
• PMID: 14675617 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA

Topics

• Acquired Immunodeficiency Syndrome (cerebrospinal fluid, complications, virology)
• Adult
• DNA (metabolism)
• Female
• Humans
• JC Virus (genetics, isolation & purification)
• Leukoencephalopathy, Progressive Multifocal (cerebrospinal fluid, complications, virology)
• Magnetic Resonance Imaging
• Polymerase Chain Reaction (methods)