[Radioimmunotherapy in patients with ovarian cancer in complete remission after the first line surgery and chemotherapy after second look laparoscopy procedure].

Abstract

OBJECTIVES:

The aim of the study was analysed a chance to successful radioimmunotherapy in patients with ovarian cancer as a consolidation procedure.

DESIGN:

Between 2000 and 2002 we introduced 56 patients into consolidation study with radioimmunotherapy after second look laparoscopy.

MATERIALS AND METHODS:

17 patients during screening procedure have failed--mostly with positive CT scans (9/17). We have done 39 laparoscopies. Among 11 patients during laparoscopy we have found in 6 cases a residual disease and in 5 cases adhesions in abdomen or pelvis and this group was excluded from study. The remaining 28 patients were divided into two groups--14 in active and 14 in control arm.

RESULTS:

Only 50% of patients with ovarian cancer in complete clinical remission after first line surgery and chemotherapy can be candidates to consolidation therapy. Among patients subjected to laparoscopy in 70% there was no evidence of macroscopic disease and adhesions.

CONCLUSIONS:

Only 50% patients in complete clinical remission after first line surgery and chemotherapy have chance to successful radioimmunotherapy.

• Authors: Janina Markowska, Radosław Madry, Jerzy Kierzkowski, Julian Malicki, Andrzej Roszak, Jolanta Lubin, Krystyna Bratos
• Journal: Ginekologia polska (Ginekol Pol) Vol. 74 Issue 9 Pg. 799-804 (Sep 2003) ISSN: 0017-0011 [Print] Poland
• Vernacular Title: Zastosowanie radioimmunoterapii u chorych na raka jajnika w fazie całkowitej remisji klinicznej po I rzutowym leczeniu chemicznym potwierdzonym operacja typu second look--ocena etapu kwalifikacji do procedury oraz jej wykonania.
• PMID: 14674127 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Iodine Radioisotopes

Topics

• Antibodies, Monoclonal (therapeutic use)
• Female
• Humans
• Iodine Radioisotopes (therapeutic use)
• Laparoscopes
• Ovarian Neoplasms (radiotherapy, surgery)
• Radioimmunotherapy (methods)
• Remission Induction
• Retrospective Studies
• Second-Look Surgery (instrumentation)
• Time Factors
• Treatment Outcome