ACE inhibition in the treatment of children after renal transplantation.

Abstract

Currently, there are no data available on long-term effects of angiotensin-converting enzyme inhibitors (ACE-I) on graft function in children after renal transplantation. We therefore analyzed all children who were transplanted at our institution between 1989 and 1998 and followed for at least 2 years. Those treated with ACE-I, mainly because of failure of other antihypertensive medications, were compared to those without ACE-I. The ACE-I-treated children ( n=19) showed significantly better blood pressure control during the 1st year of follow-up ( p<0.05). In children with chronic allograft dysfunction ( n=8), treatment with ACE-I stabilized graft function, with improvement in creatinine clearance in 50% ( p<0.01). Serum potassium and hemoglobin levels remained stable. One patient discontinued ACE-I because of renal artery stenosis. Taken together, ACE-I were effective and safe in the treatment of hypertension in children following renal transplantation. Children with chronic allograft dysfunction experienced a stabilizing effect on graft function.

• Authors: Klaus Arbeiter, Andrea Pichler, Regina Stemberger, Thomas Mueller, Dagmar Ruffingshofer, Regina Vargha, Egon Balzar, Christoph Aufricht
• Journal: Pediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 19 Issue 2 Pg. 222-6 (Feb 2004) ISSN: 0931-041X [Print] Germany
• PMID: 14673630 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Creatinine

Topics

• Adolescent
• Angiotensin-Converting Enzyme Inhibitors (adverse effects, therapeutic use)
• Blood Pressure (drug effects)
• Child
• Child, Preschool
• Creatinine (metabolism)
• Female
• Humans
• Hypertension (drug therapy, etiology)
• Kidney (drug effects, physiopathology)
• Kidney Diseases (drug therapy, etiology)
• Kidney Transplantation (adverse effects)
• Male
• Postoperative Care
• Postoperative Period
• Retrospective Studies