Hydroxyurea-induced pneumonitis in a patient with chronic idiopathic myelofibrosis after prolonged drug exposure.

Abstract

We describe a 63-yr-old patient diagnosed with chronic idiopathic myelofibrosis whose disease was treated with hydroxyurea for 2 yr. He developed respiratory symptoms that were extensively investigated including lung biopsy. Clinical, radiological and histological features were compatible with a diagnosis of hydroxyurea-induced pneumonitis. Following drug withdrawal there was remarkable improvement in clinical and radiological findings.

• Authors: Chi C Wong, David Brown, Sarah J Howling, Norman E Parker
• Journal: European journal of haematology (Eur J Haematol) Vol. 71 Issue 5 Pg. 388-90 (Nov 2003) ISSN: 0902-4441 [Print] England
• PMID: 14667203 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hydroxyurea

Topics

• Diagnosis, Differential
• Humans
• Hydroxyurea (adverse effects)
• Male
• Middle Aged
• Pneumonia (chemically induced, diagnosis)
• Primary Myelofibrosis (complications, drug therapy)