[Flurbiprofen: therapeutic alternative in nephritic colic].

Abstract

A double blind randomized study was conducted in 52 patients with renoureteric colic to compare the therapeutic efficacy of two analgesics given in a single intramuscular dose. Following the administration of 2 gm dipirone plus 20 mg hyoscine N-butylbromide (n = 26) or 150 mg flurbiprofen (n-26), the patients were assessed for pain intensity, relief and pain status for a period of one hour. Both treatments afforded a similar analgesic effect, with pain remitting in 76.9% of the cases. No significant differences were observed for the latency periods or degree of pain at 5, 10, 30 and 60 minutes following treatment. Additional analgesic therapy was required in 34.6% of the patients who received dipirone and 26.9% of the flurbiprofen group, the difference not being statistically significant. Overall both drugs were well tolerated and only local adverse effects were observed, pain being the most frequent.

• Authors: M Julián Mora, J Extramiana, F J Navarro, M Arrizabalaga, A Mañas, P González, M J Pérez, P Paniagua
• Journal: Archivos espanoles de urologia (Arch Esp Urol) Vol. 45 Issue 8 Pg. 773-7 (Oct 1992) ISSN: 0004-0614 [Print] Spain
• Vernacular Title: Flurbiprofen: alternativa terapéutica en el dolor del cólico nefrítico.
• PMID: 1466576 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Flurbiprofen
• Dipyrone
• Scopolamine

Topics

• Adult
• Aged
• Colic (complications, drug therapy)
• Dipyrone (administration & dosage, therapeutic use)
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Flurbiprofen (therapeutic use)
• Humans
• Kidney Calculi (complications)
• Kidney Diseases (drug therapy)
• Male
• Middle Aged
• Scopolamine (administration & dosage, therapeutic use)