Abstract |
We have examined the effect of systemically administered galnon, a novel low-molecular weight agonist of galanin receptors, on neuropathic pain-like behaviors in rats after photochemically induced partial nerve injury. Galnon is a galanin receptor ligand with moderate affinity to spinal cord membranes (K(D) of 6+/-0.6 microM). While intraperitoneally applied galnon produced no significant effect on mechanical or cold hypersensitivity, it dose-dependently prolonged heat withdrawal latency in nerve-injured rats. The effect of galnon was more potent on the injured side which has significantly shorter latency than the contralateral side. The anti-hyperalgesic effect of galanon was prevented by intrathecal M35, a galanin receptor antagonist. No side effects, such as sedation or motor impairment, were seen following systemic galnon treatment at the doses used. It is concluded that systemic galnon alleviated heat-hyperalgesic response in rats with partial sciatic nerve injury. This effect was likely to be mediated by activation of spinal galanin receptors.
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Authors | Wei-Ping Wu, Jing-Xia Hao, Linda Lundström, Zsuzsanna Wiesenfeld-Hallin, Ulo Langel, Tamas Bartfai, Xiao-Jun Xu |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 482
Issue 1-3
Pg. 133-7
(Dec 15 2003)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 14660014
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 7-((9-fluorenylmethoxycarbonyl)cyclohexylalanyllysyl)amino-4-methylcoumarin
- Coumarins
- Receptors, Galanin
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Topics |
- Animals
- Coumarins
(administration & dosage)
- Hot Temperature
(adverse effects)
- Hyperalgesia
(drug therapy)
- Male
- Pain Measurement
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Receptors, Galanin
(agonists, physiology)
- Sciatic Neuropathy
(drug therapy)
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