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Systemic galnon, a low-molecular weight galanin receptor agonist, reduces heat hyperalgesia in rats with nerve injury.

Abstract
We have examined the effect of systemically administered galnon, a novel low-molecular weight agonist of galanin receptors, on neuropathic pain-like behaviors in rats after photochemically induced partial nerve injury. Galnon is a galanin receptor ligand with moderate affinity to spinal cord membranes (K(D) of 6+/-0.6 microM). While intraperitoneally applied galnon produced no significant effect on mechanical or cold hypersensitivity, it dose-dependently prolonged heat withdrawal latency in nerve-injured rats. The effect of galnon was more potent on the injured side which has significantly shorter latency than the contralateral side. The anti-hyperalgesic effect of galanon was prevented by intrathecal M35, a galanin receptor antagonist. No side effects, such as sedation or motor impairment, were seen following systemic galnon treatment at the doses used. It is concluded that systemic galnon alleviated heat-hyperalgesic response in rats with partial sciatic nerve injury. This effect was likely to be mediated by activation of spinal galanin receptors.
AuthorsWei-Ping Wu, Jing-Xia Hao, Linda Lundström, Zsuzsanna Wiesenfeld-Hallin, Ulo Langel, Tamas Bartfai, Xiao-Jun Xu
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 482 Issue 1-3 Pg. 133-7 (Dec 15 2003) ISSN: 0014-2999 [Print] Netherlands
PMID14660014 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 7-((9-fluorenylmethoxycarbonyl)cyclohexylalanyllysyl)amino-4-methylcoumarin
  • Coumarins
  • Receptors, Galanin
Topics
  • Animals
  • Coumarins (administration & dosage)
  • Hot Temperature (adverse effects)
  • Hyperalgesia (drug therapy)
  • Male
  • Pain Measurement (drug effects)
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Galanin (agonists, physiology)
  • Sciatic Neuropathy (drug therapy)

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