Preoperative treatment with oestradiol in women scheduled for vaginal operation for genital prolapse. A randomised, double-blind trial.

Abstract

OBJECTIVE:

To disclose a clinical and histopathological effect of local low-dose oestradiol treatment on the vagina.

DESIGN:

A randomised, double-blind trial.

SETTING:

Two gynaecological departments at University Hospitals.

SUBJECTS:

Forty-eight postmenopausal women scheduled for surgery because of genital prolapse.

INTERVENTION:

25 micrograms oestradiol or placebo, administered as vaginal pessaries daily, 3 weeks prior to surgery.

MAIN OUTCOME MEASURES:

Cytological, histological and clinical changes of the vaginal mucosa.

RESULTS:

The thickness of the vaginal wall increased as did the oestrogenic index. No clinical effect was seen apart from decreased incidence of recurrent cystitis postoperatively.

CONCLUSIONS:

Preoperative oestrogen treatment has been shown to reduce the incidence of recurrent cystitis and may be needed for stimulation of vaginal mucosa; the short-term clinical effect is not convincing, however.

• Authors: C Felding, A L Mikkelsen, H V Clausen, A Loft, L G Larsen
• Journal: Maturitas (Maturitas) Vol. 15 Issue 3 Pg. 241-9 (Dec 1992) ISSN: 0378-5122 [Print] Ireland
• PMID: 1465038 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Estradiol

Topics

• Administration, Intravaginal
• Adult
• Aged
• Aged, 80 and over
• Atrophy
• Biopsy, Needle
• Cystitis (etiology, prevention & control)
• Double-Blind Method
• Estradiol (administration & dosage)
• Female
• Humans
• Middle Aged
• Pessaries
• Postoperative Complications (prevention & control)
• Preoperative Care
• Uterine Prolapse (surgery)
• Vagina (pathology)
• Vaginal Smears