Low doses of topiramate are effective in essential tremor: a report of three cases.

Abstract

We here report on 3 patients with essential tremor, otherwise unresponsive to pharmacological treatment, who greatly benefited from low doses of topiramate (50 mg/d). No side effects were observed and improvement was sustained during a mean of 7 months (range 3-12 months) follow up. Our results suggest that topiramate titration should be performed gradually, so as not to neglect cases responsive to low doses.

• Authors: Emilia M Gatto, M Claudia Uribe Roca, Gabriela Raina, Federico Micheli
• Journal: Clinical neuropharmacology (Clin Neuropharmacol) 2003 Nov-Dec Vol. 26 Issue 6 Pg. 294-6 ISSN: 0362-5664 [Print] United States
• PMID: 14646607 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Anticonvulsants
• Neuroprotective Agents
• Topiramate
• Primidone
• Fructose
• Propranolol

Topics

• Adrenergic beta-Antagonists (therapeutic use)
• Aged
• Anticonvulsants (administration & dosage, adverse effects, therapeutic use)
• Bipolar Disorder (complications, physiopathology)
• Dose-Response Relationship, Drug
• Essential Tremor (drug therapy)
• Fructose (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Humans
• Male
• Neuroprotective Agents (administration & dosage, adverse effects, therapeutic use)
• Neuropsychological Tests
• Primidone (therapeutic use)
• Propranolol (therapeutic use)
• Topiramate