Abstract | AIM: METHODS: The study was divided into seven periods: (1) HCTZ and acemetacin; (2) control period; (3) HCTZ; (4) a second control period; (5) HCTZ and amiloride; (6) a third control period, and (7) HCTZ and triamterene. Fluid intake, urine volume, urinary Na, K, creatinine, and osmolality and serum Na, K, Cl, CO2, and osmolality were measured, and free water clearance and proximal and distal tubular Na reabsorption rates were calculated. RESULTS: Without drug administration, the urine volume was about 8,000 ml/day. The urine volume was reduced to about 6,000 ml/day with HCTZ. A further urine volume reduction to about 5,000 ml/day was obtained with the second drug administration, and the effects were similar among the three regimens. Serum and urinary osmolality and free water clearance were also similar among the three combinations, whereas the urinary potassium excretion was the least, and the serum potassium concentration was the highest with HCTZ plus amiloride. Besides, no alkalosis was observed only with this combination. CONCLUSION:
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Authors | Tadashi Konoshita, Masahiro Kuroda, Takashi Kawane, Ichiro Koni, Isamu Miyamori, Yohei Tofuku, Hiroshi Mabuchi, Ryoyu Takeda |
Journal | Hormone research
(Horm Res)
Vol. 61
Issue 2
Pg. 63-7
( 2004)
ISSN: 0301-0163 [Print] Switzerland |
PMID | 14646392
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright 2004 S. Karger AG, Basel |
Chemical References |
- Diuretics
- Hydrochlorothiazide
- Amiloride
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Topics |
- Adult
- Amiloride
(therapeutic use)
- Diabetes Insipidus, Nephrogenic
(congenital, drug therapy)
- Diuretics
(therapeutic use)
- Drug Therapy, Combination
- Humans
- Hydrochlorothiazide
(therapeutic use)
- Male
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