Abstract | BACKGROUND: METHODS AND RESULTS: CONCLUSIONS: The present studies demonstrate that plasmalogens are attacked by MPO-derived reactive chlorinating species within human atheroma. The resultant species formed, alpha-chloro fatty aldehydes and unsaturated lysophospholipids, possess proatherogenic properties, as shown by induction of P-selectin surface expression in primary human coronary artery endothelial cells.
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Authors | Arun K Thukkani, Jane McHowat, Fong-Fu Hsu, Marie-Luise Brennan, Stanley L Hazen, David A Ford |
Journal | Circulation
(Circulation)
Vol. 108
Issue 25
Pg. 3128-33
(Dec 23 2003)
ISSN: 1524-4539 [Electronic] United States |
PMID | 14638540
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- 2-chlorohexadecanal
- Aldehydes
- Fatty Acids
- Fatty Acids, Unsaturated
- Hydrocarbons, Chlorinated
- Lysophosphatidylcholines
- P-Selectin
- Plasmalogens
- fatty aldehyde
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Topics |
- Aldehydes
(analysis)
- Animals
- Aorta
(chemistry, pathology)
- Arteriosclerosis
(metabolism, pathology)
- Cells, Cultured
- Endothelium, Vascular
(drug effects, metabolism)
- Fatty Acids
(analysis)
- Fatty Acids, Unsaturated
(analysis)
- Humans
- Hydrocarbons, Chlorinated
(analysis)
- Lysophosphatidylcholines
(analysis, chemistry, pharmacology)
- Mice
- P-Selectin
(metabolism)
- Plasmalogens
(chemistry, metabolism)
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