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Clinical and [99mTc]TRODAT-1/[123I]IBZM SPECT imaging findings in dopa-responsive dystonia.

Abstract
We report the clinical and dopamine transporter/D2 receptor single-photon emission computed tomographic (SPECT) imaging findings in a 39-year-old woman with a 24-year history of dopa-responsive dystonia (DRD). The SPECT imaging of the dopamine transporter with [(99m)Tc]TRODAT-1 is helpful in differentiating DRD from early-onset idiopathic parkinsonism. In the later clinical course, the [(123)I]IBZM SPECT is also helpful in differentiating these two conditions. The patient showed a dramatic and sustained response to levodopa, and needed a smaller dose of levodopa for symptom control in the later course.
AuthorsWen-Juh Hwang, Wei-Jen Yao, Shiaw-Pyng Wey, Gann Ting
JournalEuropean neurology (Eur Neurol) Vol. 51 Issue 1 Pg. 26-9 ( 2004) ISSN: 0014-3022 [Print] Switzerland
PMID14631126 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 2004 S. Karger AG, Basel
Chemical References
  • Benzamides
  • Contrast Media
  • Dopamine Agents
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Organotechnetium Compounds
  • Pyrrolidines
  • Radiopharmaceuticals
  • Receptors, Dopamine D2
  • Tropanes
  • technetium Tc 99m TRODAT-1
  • Levodopa
  • 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide
Topics
  • Adult
  • Benzamides
  • Brain (diagnostic imaging, metabolism)
  • Contrast Media
  • Diagnosis, Differential
  • Dopamine Agents (therapeutic use)
  • Dopamine Plasma Membrane Transport Proteins
  • Dystonia (diagnostic imaging, drug therapy, metabolism)
  • Female
  • Humans
  • Levodopa (therapeutic use)
  • Membrane Glycoproteins
  • Membrane Transport Proteins (metabolism)
  • Nerve Tissue Proteins
  • Organotechnetium Compounds
  • Parkinsonian Disorders (diagnosis)
  • Pyrrolidines
  • Radiopharmaceuticals
  • Receptors, Dopamine D2 (metabolism)
  • Tomography, Emission-Computed, Single-Photon (methods)
  • Tropanes

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