Abstract |
We report the clinical and dopamine transporter/D2 receptor single-photon emission computed tomographic (SPECT) imaging findings in a 39-year-old woman with a 24-year history of dopa-responsive dystonia (DRD). The SPECT imaging of the dopamine transporter with [(99m)Tc]TRODAT-1 is helpful in differentiating DRD from early-onset idiopathic parkinsonism. In the later clinical course, the [(123)I] IBZM SPECT is also helpful in differentiating these two conditions. The patient showed a dramatic and sustained response to levodopa, and needed a smaller dose of levodopa for symptom control in the later course.
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Authors | Wen-Juh Hwang, Wei-Jen Yao, Shiaw-Pyng Wey, Gann Ting |
Journal | European neurology
(Eur Neurol)
Vol. 51
Issue 1
Pg. 26-9
( 2004)
ISSN: 0014-3022 [Print] Switzerland |
PMID | 14631126
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright 2004 S. Karger AG, Basel |
Chemical References |
- Benzamides
- Contrast Media
- Dopamine Agents
- Dopamine Plasma Membrane Transport Proteins
- Membrane Glycoproteins
- Membrane Transport Proteins
- Nerve Tissue Proteins
- Organotechnetium Compounds
- Pyrrolidines
- Radiopharmaceuticals
- Receptors, Dopamine D2
- Tropanes
- technetium Tc 99m TRODAT-1
- Levodopa
- 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide
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Topics |
- Adult
- Benzamides
- Brain
(diagnostic imaging, metabolism)
- Contrast Media
- Diagnosis, Differential
- Dopamine Agents
(therapeutic use)
- Dopamine Plasma Membrane Transport Proteins
- Dystonia
(diagnostic imaging, drug therapy, metabolism)
- Female
- Humans
- Levodopa
(therapeutic use)
- Membrane Glycoproteins
- Membrane Transport Proteins
(metabolism)
- Nerve Tissue Proteins
- Organotechnetium Compounds
- Parkinsonian Disorders
(diagnosis)
- Pyrrolidines
- Radiopharmaceuticals
- Receptors, Dopamine D2
(metabolism)
- Tomography, Emission-Computed, Single-Photon
(methods)
- Tropanes
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