HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathology.

Abstract
A genetic association of an intronic single nucleotide polymorphism site of heparan sulfate proteoglycan 2 (HSPG2) with Alzheimer's disease (AD) was investigated among Finnish AD patients (n=213) and controls (n=269). No association of the HSPG2 polymorphism alone was observed with AD. However, an association of HSPG2 A allele with AD was detected in apolipoprotein (APOE) epsilon4 allele carriers. The odds ratio for AD was doubled in subjects carrying both epsilon4 and HSPG2 A alleles (OR=6.6) when compared to subjects with epsilon4 allele alone (OR=3.1). The impact of HSPG2 polymorphism on beta amyloid and tau pathology was studied using immunohistochemistry. Paired helical filament labeling was significantly more pronounced in AD patients carrying both epsilon4 and HSPG A alleles when compared to epsilon4 carriers lacking the HSPG2 A allele. In conclusion, HSPG2 A allele may possess an additive risk effect among the APOE epsilon4 carriers in AD.
AuthorsSusan Iivonen, Seppo Helisalmi, Arto Mannermaa, Irina Alafuzoff, Maarit Lehtovirta, Hilkka Soininen, Mikko Hiltunen
JournalNeuroscience letters (Neurosci Lett) Vol. 352 Issue 2 Pg. 146-50 (Dec 04 2003) ISSN: 0304-3940 [Print] Ireland
PMID14625044 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Apolipoprotein E4
  • Apolipoproteins E
  • Heparan Sulfate Proteoglycans
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease (genetics)
  • Apolipoprotein E4
  • Apolipoproteins E (genetics)
  • Confidence Intervals
  • Female
  • Gene Frequency (genetics)
  • Genotype
  • Heparan Sulfate Proteoglycans (genetics)
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic (genetics)
  • Statistics, Nonparametric

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: