[Influence of delta-sleep-inducing peptide on the activity of proteolytic enzymes in the rat brain under hypokinesia].

Abstract

Single administration of the delta-sleep-inducing peptide (DSIP) in a dose of 12 micrograms/100 g to intact animals makes the activity of neutral proteinases and cathepsin D higher in the rat brain and blood serum. Hypokinesia of different duration changes activity of neutral and acidic proteinases and induces accessibility of cathepsin D to the cytosol as a result of damage in lysosomal membrane. Injection DSIP induces a decrease A/B of cathepsin D to the control level under 1-h hypokinesia condition and normalizes the neutral proteolytic activity under 6-h hypokinesia condition.

• Authors: A M Mendzheritskiĭ, A V Lysenko, I I Mikhaleva
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1992 Sep-Oct Vol. 64 Issue 5 Pg. 37-42 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Vliianie del'ta-son-indutsiruiushchego peptida na aktivnost' proteoliticheskikh fermentov v mozge krys pri gipokinezii.
• PMID: 1462368 (Publication Type: English Abstract, Journal Article)

Chemical References

• Delta Sleep-Inducing Peptide
• Peptide Hydrolases
• Cathepsin D

Topics

• Animals
• Brain (drug effects, enzymology)
• Cathepsin D (blood, drug effects, metabolism)
• Delta Sleep-Inducing Peptide (pharmacology)
• Female
• Male
• Peptide Hydrolases (blood, drug effects, metabolism)
• Rats
• Reference Values
• Restraint, Physical
• Stress, Physiological (enzymology)