Early kidney transplantation may prevent aluminium-related bone disease.

Abstract

In uraemia patients aluminium (Al) accumulation in bone leads to low turn-over bone disease. Al-related bone disease causes bone pain, non-traumatic fractures and hypercalcaemia, and does not respond to treatment with vitamin D compounds. Al-contaminated dialysate and ingestion of Al-containing phosphate binding agents are the main risk factors for bone Al accumulation. Studies of selected patients have indicated that Al-related bone disease ameliorates after successful kidney transplantation, but systematic studies of bone Al have not been reported. In a prospective study we investigated the effect of successful kidney transplantation on bone Al and clinical bone disease.

• Authors: K P Nordal, E Dahl, J Halse, A Flatmark
• Journal: Transplant international : official journal of the European Society for Organ Transplantation (Transpl Int) Vol. 5 Suppl 1 Pg. S98-9 ( 1992) ISSN: 0934-0874 [Print] Switzerland
• PMID: 14621745 (Publication Type: Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Immunosuppressive Agents
• Cyclosporine
• Creatinine
• Aluminum

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Aluminum (pharmacokinetics, toxicity)
• Biopsy
• Bone Diseases (chemically induced, prevention & control)
• Bone and Bones (drug effects, metabolism, pathology)
• Creatinine (blood)
• Cyclosporine (therapeutic use)
• Follow-Up Studies
• Humans
• Immunosuppressive Agents (therapeutic use)
• Kidney Transplantation (mortality, pathology, physiology)
• Time Factors