Abstract | BACKGROUND: METHODS: In the present study, the quantity of the renal amyloid mass before and more than 3 years after high-dose melphalan treatment and autologous blood stem cell transplantation was assessed in two patients. At the time of the second renal biopsy, both patients were in complete remission without detectable serum and urinary monoclonal IgA-lambda and a normal percentage of plasma cells in the bone marrow. RESULTS: CONCLUSION: Despite complete remission of the plasma cell dyscrasia and improvement of glomerular permeability, the amount of glomerular amyloid mass did not regress.
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Authors | Martin Zeier, Jolanta Perz, Reinhold P Linke, Ugo Donini, Rüdiger Waldherr, Konrad Andrassy, Anthony D Ho, Hartmut Goldschmidt |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 18
Issue 12
Pg. 2644-7
(Dec 2003)
ISSN: 0931-0509 [Print] England |
PMID | 14605290
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Amyloid
- Antineoplastic Agents, Alkylating
- Melphalan
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Topics |
- Amyloid
(analysis)
- Amyloidosis
(pathology, physiopathology, therapy)
- Antineoplastic Agents, Alkylating
(therapeutic use)
- Female
- Hematopoietic Stem Cell Transplantation
(methods)
- Humans
- Kidney Diseases
(immunology, pathology, physiopathology, therapy)
- Male
- Melphalan
(therapeutic use)
- Middle Aged
- Paraproteinemias
(pathology, physiopathology, therapy)
- Remission Induction
- Transplantation, Autologous
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