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Dynamic investigation for evaluation of calcium metabolism and parathyroid function.

Abstract
Differently from other metabolic conditions, most of calcium metabolism disorders are diagnosed through simple detection of both serum and urinary excretion (24-h urine collection), levels of calcium, total and ionized form, and phosphate, and of calciotropic hormone serum levels, such as calcitonin, PTH and vitamin D metabolites. For the diagnosis and clinical monitoring of some metabolic bone diseases, such as osteoporosis and Paget's disease, the assessment of bone turnover is offering a useful tool for the evaluation of the therapeutic response in affected individuals. Markers of bone formation are represented by bone alkaline phosphatase and osteocalcin, while principal bone resorption markers are represented by pyridinoline, deoxypyridinoline and crosslinks of collagen N-telopeptide, both in the 24-h and fasting second morning urine collection. Only in selected conditions, here briefly reviewed, dynamic tests can offer an interpretation on the pathogenetic events causing a disorder of calcium metabolism.
AuthorsF Cioppi, A Falchetti, L Masi, M L Brandi
JournalJournal of endocrinological investigation (J Endocrinol Invest) Vol. 26 Issue 7 Suppl Pg. 83-91 ( 2003) ISSN: 0391-4097 [Print] Italy
PMID14604070 (Publication Type: Journal Article, Review)
Chemical References
  • Parathyroid Hormone
  • Pentagastrin
  • Calcium
  • Strontium
Topics
  • Adult
  • Bone Diseases, Metabolic (diagnosis, physiopathology)
  • Calcium (blood, metabolism, urine)
  • Calcium Metabolism Disorders (diagnosis, physiopathology)
  • Diagnostic Techniques, Endocrine
  • Feedback, Physiological
  • Female
  • Humans
  • Parathyroid Diseases (diagnosis, physiopathology)
  • Parathyroid Glands (physiopathology)
  • Parathyroid Hormone (blood)
  • Pentagastrin
  • Strontium

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